Keen to find whether a non-invasive alternative could be used, researchers tested frequency magnetic resonance imaging (fMRI) and computed tomography (CT) scanners in 182 adult deaths where the corpse was afterwards given an autopsy. Autopsy was not needed in a third of cases that had been imaged by fMRI and in half of the cases imaged by CT, according to the study.

However, the scanners were not perfect. They failed to spot, or misattributed, more than two dozen cases of heart disease as well as several dozen cases of embolism, pneumonia and intra-abdominal lesions. Screening by scanners could identify some of the major causes of death and thus make some autopsies unnecessary, the paper suggests.

It could also identify suspect lesions that would enable pathologists to carry out only a minimal dissection to pinpoint the cause of death. “When radiologists are confident that the cause of death on imaging is definite, the discrepancy rate between the radiological and autopsy diagnoses is lower and might be acceptable from a medico-legal point of view,” says the study, headed by Ian Roberts, a professor of pathology at the John Radcliffe Hospital in Oxford.

But several practical hurdles must be overcome before any screening becomes routine. Scanners — diagnostic tools that get cross-sectional or 3-D images of internal organs — are very expensive and require specialist training to operate them and interpret their results.

“Autopsy is regarded as the gold standard for diagnosis,” said James Underwood of the University of Sheffield in a commentary. “Post-mortem imaging cannot yet be regarded as a universal substitute for autopsy; it is one of several methods available for determining the cause of death.”

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Most of the cases have been reported in Lahore, the provincial capital, where about 2,950 people tested positive.”So far, eight people have died of dengue. We are trying our best to control this epidemic,” Jehanzeb Khan, secretary of the provincial health department, told Reuters.

Health experts say the illness is spreading across the Punjab because of poor hygiene conditions, and heavy monsoon rain provides ideal conditions for dengue-carrying mosquitoes to thrive in stagnant waters. The first case of dengue was reported in Pakistan in 1994.

Those who died included Ataullah Siddiqui, head of the provincial department of minerals and natural resources. Khan said the government had launched a fumigation drive to kill mosquitoes.

Sri Lanka is sending a team of experts to Pakistan to help fight the disease, the Sri Lankan High Commission said in a statement. Pakistan’s weak civilian government, struggling to deal with floods that have killed 266 people, has been criticized by the media for dragging its feet on the dengue issue. “The response to dengue has been adhoc, ex post, and therefore reactionary at best,” The News daily said in its editorial.

The disease is a threat to nearly half of the world’s population. Of the estimated 220 million people infected each year, two million — mostly children in Latin America and Asia — develop a severe form called dengue hemorrhagic fever. There is currently no cure or vaccine for dengue fever.

“Improving nutritional status, preventing obesity, and stressing the importance of weight loss might improve asthma control and exacerbation risk in children and decrease the incidence of asthma in adults,” researchers write in the Journal of Allergy and Clinical Immunology. Both asthma and obesity rates have soared among kids in recent decades, reaching nearly 10 percent and 17 percent today, respectively.

While some studies have hinted at a link between the two conditions, conclusions on whether heavier kids also have more severe asthma than others have been mixed.

Dr. Kenneth B. Quinto from the University of California, San Diego, and colleagues looked back at more than 32,000 kids who’d been diagnosed with asthma and were enrolled in a Kaiser Permanente health plan. Nearly half of the children were overweight or obese.

The researchers found that the heavier kids were more likely to have more than a handful of yearly prescriptions for rescue inhalers, which contain short-acting drugs such as albuterol that open up the airways when an asthma attack is coming on.

On average, normal-weight children used 2.8 rescue inhalers a year, whereas obese kids used 3.1.

The heavy youngsters also used more inhaled steroids, such as Pulmicort or Flovent, which are a mainstay treatment to keep airway inflammation under control on a daily basis in asthmatics.

And the results held up after Quinto and his colleagues accounted for alternative explanations of the differences, such as sex, race, diabetes and parents’ education levels.

The team speculates that the extra pounds might be weighing on the lungs, making obese kids feel like they need more medication. Scientists have also found that overweight people don’t respond as well as others to steroids, which might help explain the new findings.

Still, in an observational study like theirs, the researchers warn it’s never possible to be certain what causes what. So whether bigger waistlines should be blamed for the extra flare-ups remains an open question.

Meanwhile, the team writes, “The best time for prevention of obesity and nonsurgical weight reduction likely occurs in childhood.”

Instead, the review comes at the request of the government’s Vaccine Injury Compensation Program, which as the name implies, pays damages to people who are injured by vaccines. Federal law requires this type of independent review as officials update side effects on that list to be sure they agree with the latest science.

“Vaccines are important tools in preventing serious infectious disease across the lifespan, from infancy through adulthood. All health care interventions, however, carry the possibility of risk and vaccines are no exception,” said pediatrician and bioethicist Dr. Ellen Wright Clayton of Vanderbilt University, who chaired the institute panel.

Still, the report stresses that vaccines generally are safe, and it may help doctors address worries from a small but vocal anti-vaccine movement. Some vaccine-preventable diseases, including measles, are on the rise.

“I am hopeful that it will allay some people’s concerns,” Clayton said. The review echoed numerous other scientific reports that dismiss an autism link.
But it found convincing evidence of 14 side effects:

—Fever-triggered seizures, which seldom cause long-term consequences, from the measles-mumps-rubella, or MMR, vaccine.

—MMR also can cause a rare form of brain inflammation in some people with immune problems.

—The varicella vaccine against chickenpox sometimes triggers that viral infection, resulting in widespread chickenpox or a painful relative called shingles. It also occasionally can lead to pneumonia, hepatitis or meningitis.

—Six vaccines — MMR and the chickenpox, hepatitis B, meningococcal and tetanus-containing vaccines — can cause severe allergic reactions known as anaphylaxis.

—Vaccines in general sometimes trigger fainting or a type of shoulder inflammation.

There’s suggestive evidence but not proof of a few other side effects, including anaphylaxis from the human papillomavirus, or HPV, vaccine and short-term joint pain in some women and children from the MMR vaccine. On the other hand, the report cleared flu shots of blame for two long-suspected side effects: Bell’s palsy and worsening of asthma.

That doesn’t mean there aren’t other side effects — the review couldn’t find enough evidence to decide about more than 100 other possibilities. Some vaccines are just too new to link to something really rare. Another example: Flu shots have long come with a caution about rare, paralyzing Guillain-Barre syndrome, but Clayton said research hasn’t settled if that’s a coincidence since the disorder is more common during the winter. The Health Resources and Services Administration, which runs the vaccine compensation program, is reviewing the report but said it’s too early to predict if it will prompt changes to the injury list.